Four flavonoids provide special protection against allergies and inflammation – healing practice

Influence of diet on allergies

Contained in food flavonoids can increase the risk of many diseases such as diabetes, Cancer, high blood pressure, asthma and reduce allergies. Four flavonoids seem particularly beneficial against allergic diseases.

Researchers of the Pakistani University of Agriculturethe Warsaw University of Biological Sciences and the French Université du Littoral Côte d’Opale have in a study evaluation the anti-inflammatory and anti-allergic properties of flavonoids analyzed from different food sources. The results are published in the journal “Biomedicine & Pharmacotherapy” released.

What are flavonoids?

designate flavonoids bioactive compounds, which are found, for example, in vegetables, fruit and nuts. You will thanks to her anti-inflammatory, antioxidant and immunomodulating properties also linked to protection against allergies and many other chronic diseases, the team reports.

In the current research work, the chemical structurethe food sources as well as the anti-inflammatory and anti-allergic properties from different flavonoids examined.

Four flavonoids particularly effective

It turned out that the flavonoids luteolin, myricetin, kaempferol and quercetin were effective against allergy-specific cytokines in various experiments. In addition, these flavonoids also inhibited IL-4 and IL-13 synthesis in basophils and mast cells, the experts report. The results for the four flavonoids are presented in detail below.

quercetin

quercetin comes in all sorts of red, violet and green pigmented fruits and vegetables before, such as red onions, blueberries, applesred grapes, kidney beans, green leafy vegetables and green tea.

Quercetin’s anti-allergic properties are due to the Stimulating the immune system marked. In addition, quercetin works by suppressing the release of pro-inflammatory cytokines and by inhibiting histamine from mast and basophil cells anti-inflammatoryaccording to the team.

kaempfer oil

kaempfer oil is, for example, in red grapes, broccolisprouts, apples, tomatoesgreen tea, potatoes, onions, pumpkinlettuce, greens beansPeach, blackberries, raspberries and spinach.

According to the researchers, kaempferol has in studies on humans and animals antiallergic and antioxidant properties shown. For example, it attenuates Th2-driven allergic diseases in various asthma models, resulting in a Airway hypersensitivity be reduced.

In addition, kaempferol induced TNF-α in a study on human epithelial cells and eosinophils airway inflammation alleviated and in mice the allergic inflammation of the airways reduced. And kaempferol lowered the production of allergy-causing inflammatory cytokines, the team reports.

According to the researchers, in the studies evaluated, kaempferol also reduced the activity of multidrug resistance-associated protein 1 (MRP-1) and inhibited the TAK1-IKK-mediated NF-κB pathway and JNK phosphorylation in activated T cells. In addition, kaempferol improved the appearance of atopic dermatitis in mice.

myricetin

myricetin belongs to the flavonol subgroup of flavonoids. For example, it can be ingested through black tea, blueberries, walnuts or grapes. has myricetin anti-inflammatory, antioxidant and anti-allergic properties

Myricetin works allergic symptoms such as sneezing, redness, rhinorrhea and swelling counteracts what is also due to the direct binding of its ingredients histamine receptors the researchers explain. In addition, it suppresses the production of Th cell cytokines involved in allergic diseases.

luteolin

luteolin is a flavone found in red grapes, juniper berries, Lemons, artichokesgreen pepper, thyme, rosemary and oregano occurs.

According to the researchers, luteolin shows promise antiallergic and anti-inflammatory Effect. It alleviated allergy symptoms in mice Airway hypersensitivity and reduced the number of inflammatory cells and Th2 and IgE cytokines.

In studies on asthmatic rats, luteolin also had the Inflammatory reactions and autophagy in lung tissue positively affected and in mice allergic nasal infections weakened. According to the research team, luteolin also reduces the IgE content and mast cell granulation during allergy diseases.

Protection against allergies by flavonoids

Overall, the study evaluation shows that flavonoids have anti-inflammatory, antioxidant and anti-allergic properties. One nutrition, which is rich in flavonoids, could therefore help to reduce the symptoms of existing allergies and also have a preventive effect. (as)