literature
(1) Conzade R et al. Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study. Nutrients 2017; 9 (12):1276; doi:10.3390/nu9121276
(2) Lam JR, Schneider JL, Zhao W et al.: Proton Pump Inhibitor and Histamine 2 Receptor Antagonist Use and Vitamin B12 Deficiency. JAMA 2013; 310 (22): 2435–2442
(3) Yang W, Cai H, Wu H, Ji L: Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a metaanalysis. J Diabetes 2019; 11(9):729–743
(4) Stabler SP: Vitamin B12 Deficiency. N Engl J Med 2013; 368: 149-160
(5) Eussen SJPM et al. Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency. Arch Intern Med 2005; 165: 1167–1172
(6) Wang et al. Cochrane Database Syst Rev 2018 March 15; 3 (3): CD004655
(7) Andrès E, Zulfiqar AA, Serraj K, Vogel T, Kaltenbach G: Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders. J Clin Med 2018; 7(10): 304
(8th) Didangelos T et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2021, 13, 395; https://doi.org/10.3390/nu13020395
* Severe vitamin B12 deficiency should initially be treated parenterally, which can be continued with oral maintenance therapy.
** There is no oral vitamin B12 medicine in Germany with a dosage higher than 1,000 μg.
Mandatory text
B12 Anchorman®. active ingredient: Cyanocobalamin 1000 μg. Composition: 1 coated tablet containing: medicinal product. works. Ingredients: Cyanocobalamin (vitamin B12) 1000 μg. Otherwise. Ingredients: Povidone K 30, stearic acid (Ph. Eur.) [pflanzlich], montan glycol wax, lactose monohydrate, sucrose, spray-dried arabic gum, talc, calcium carbonate, titanium dioxide (E 171), white clay, macrogol 6000, macrogol glycerol hydroxystearate (Ph. Eur.), sodium dodecyl sulfate, croscarmellose sodium, hypromellose 15 mPa*s, hydroxypropyl cellulose (Ph. Eur.), medium chain triglycerides. Areas of application: Treatment of vitamin B12 deficiency states, i.e. caused by malnutrition, treatment. (maintenance therapy) of vitamin B12 deficiency states, e.g. B. as a result of impaired absorption of vitamin B12, permanent treatment. a pernicious anemia induced by vitamin B12 deficiency after normalization d. Blood values. The treatment egg. pernicious anemia or neurological. Symptoms are administered parenterally at the beginning until they return to normal. Blood values. B12 Anchorman® is recommended for adults. Contraindications: Known hypersensitivity to Cyanocobalamin or a d. otherwise. Passes. B12 Anchorman® must not be used to treat megaloblastic anemia, i.e. exclusively caused by a folic acid deficiency. B12 Anchorman® must not be used on patients, i.e. must undergo cyanide detoxification (e.g. patients with tobacco-related amblyopia or retrobulbar neuritis in pernicious anemia). In these cases, another cobalamin derivative must be administered. Patients with B12 deficiency who are at risk of Leber optic atrophy may be treated. B12 deficiency cannot be treated with cyanocobalamin. B12 Anchorman® May not be used in patients with amblyopia caused by tobacco or alcohol. Side effects: Uncommon: Severe hypersensitivity reactions, i.e. can manifest in the form of hives, rashes or itching in large areas of the body. Frequency not known: acne-like skin reactions, blistering, fever. For more information see specialist information! Pharmacy required. Wörwag Pharma GmbH & Co. KG, 71034 Böblingen. As of: 11/2022