Fentanyl’s powerful pull comes from both the potent, rapid euphoria people feel while on the drug and the devastating symptoms of withdrawal. Researchers have now zeroed in on brain circuits responsible for these two forces of fentanyl addiction.
The study in mice, reported May 22 in Nature, suggests two distinct brain pathways are in play.
“Addiction is not a simple disorder — it’s very complex and dynamic,” says Mary Kay Lobo, a neuroscientist at the University of Maryland School
A single moment was all it took for our world to be seismically changed for ever. In 2008, my husband, Simon — a relentlessly, even irritatingly, healthy 38-year-old musician and part-time construction worker — fell backwards off an unsecured second-storey scaffold on to a stone floor, suffering catastrophic injuries to his brain and spinal cord.
Rushed to hospital by air ambulance, the head neurosurgeon later told us that when Simon had arrived in his operating room he was ‘half way
DENVER — A weight-loss drug used to treat obesity and diabetes has shown promise to treat another disorder: opioid addiction.
Early results from a small clinical trial, presented February 17 at the annual meeting of the American Association for the Advancement of Science, suggest that a close relative of the weight-loss drugs Wegovy and Ozempic significantly lessened cravings for opioids in people with opioid use disorder.
“For them to have any time when they might be free of that craving
Gesundheit
29. August 2023 | 19.00
Einer neuen Studie zufolge könnte eine Unterklasse synthetischer Opioide namens Nitazene wirksamer sein als Fentanyl – und 1.000-mal wirksamer als Morphin.
Die kleine Studie, die am Dienstag in JAMA Network Open veröffentlicht wurde, ergab, dass Patienten, die Nitazene überdosiert hatten, zwei oder mehr Dosen Naloxon erhalten mussten, ein Medikament, das eine Medikamentenüberdosis rückgängig macht.
Im Vergleich dazu benötigten Patienten nach einer Überdosis Fentanyl nur eine Dosis Naloxon.
Nitazene sind im Labor
The Sackler family, once regarded as a beacon for philanthropic giving, got a major break in a bankruptcy settlement shielding them from criminal charges for their role in fueling a deadly opioid crisis that has killed more than 650,000 people.
OxyContin was the star of drug-maker Purdue Pharma’s portfolio, which proved a cash cow for the mega-elite Sacklers who at one point were worth $13 billion and used their fortune to fund whole museum wings, hospitals, and university departments.
Members
Lisa Marie Presley was trying to lose weight for the Elvis awards season and was even taking opioids in the weeks before her death, family sources have claimed.
The star underwent plastic surgery two months before the Golden Globes and lost up to 50 pounds as part of a strict regimen, insiders told TMZ.
At the awards show just days before her sudden death from cardiac arrest at her California, home, the 54-year-old was seen slurring her words and appeared
